Uncovering Gene Expression Regulation in Bone Metabolism

anti-RUNX2 anti-GR DAPI

ST2/Rx2 dox cells


The repair of a fractured bone is a complex biological event that essentially recapitulates embryonic development. Understanding the spatiotemporal gene expression during the bone healing progression will ultimately enable us to comprehend the essential process of remodeling.


How binding states of functionally related transcription factors are affected by the underlying chromatin state in bone metabolism? We are currently investigating how Odd-paired/ZIC and Runt/RUNX function to alter the chromatin structure. Additionally, RNA live-imaging will help us detect temporal gene expression variations in bone cells upon transcription dynamic input.